oncogene|oncogenes in English

noun

['ɑŋkəʊdʒɪːn /'ɒn-]

(Medical) mutated gene that may result in the onset of cancer in an animal or huma

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1. The EGF receptor is a product of the erb-B oncogene.

2. The GRO1 oncogene (melanoma growth-stimulating activity alpha)_has been localized in region 4q21.

3. To be familiar with common oncogenes and its product, tumor suppressor genes and its products.

4. Various mutations in both oncogenes and tumour suppressor genes have been implicated heavily in the development of cancer.

5. Plainly in any less desperate case the risk of activating oncogenes would absolutely forbid the use of such a drug.

6. Exons 10, 11, 13, 14, 15 and 16 of the RET proto-oncogene were amplified in polymerase chain reactions.

7. Perhaps the most exciting of future possibilities for genetic intervention in cancer is the direct manipulation of oncogenes or tumour suppressor genes.

8. We now know that oncogenes as well as tumour suppressors maintain metabolic homeostasis and that alterations in these genes result in a metabolic switch.

9. Conclusion:The effect of Weiyankang plus gastrone on precancerosis of gastric cancer may due to repress the abnormal expression of oncogene proteins in gastric mucosa.

10. Bitt has developed a platform for targeting the tumor necrosis factor receptor 2 (TNFR2) oncogene and the potent population of TNFR2 Tregs in the tumor microenvironment.

11. Antagonises TLR-mediated production of NF-kB – reducing inflammation, potentially downregulating oncogenes Taking Naltrexone in larger doses of 50-300mg seems to negate the immunomodulatory effect by overwhelming the receptors, so for the effect to work, the dose must be in the range of 0.5-10mg, usually maxing at 4.5mg in clinical experience.

12. On the basis of the Bicyclic pyridopyrimidinone framework of the first-in-class clinical KRAS G12C inhibitor AMG510, a sc … KRAS is the most commonly altered oncogene of the RAS family, especially the G12C mutant (KRAS<sup>G12C</sup>), which has been a promising drug target for many cancers.

13. The detection of amylase in acinic cell carcinomas, and the detection of steroid hormone receptors in these and other malignant salivary gland tumors particularly in combination with the expression of transcription factors, oncogenes and proliferation associated antigens result in characteristic expression profiles. These may prove to be valuable for further investigations, especially on the molecular level.